Xiaozhe received his BS from Tsinghua University, Bejing, China in 2014. California Institute of Technology. . This minor is intended to supplement one of Caltech's undergraduate degrees and is designed for students who wish to broaden their knowledge beyond their normal major, especially for those who wish to join the structural engineering profession after graduation or pursue a graduate degree in structural mechanics or structural engineering. The journal was established in 2001 and is published by BioMed Central. We are fundamentally biochemists who want to know how the cell works at the atomic level. RIKEN SPring-8 Center, Hyogo 679-5148, Japan. Courtney Oaida BMB Graduate Option Manager Phone: (626) 395-6446 Office: 162 Crellin E-mail: coaida@caltech.edu Bil Clemons Option Representative Phone: (626) 395-1796 Office: 157 Broad Center E-mail: clemons@caltech.edu. The research interests of the Rees group have centered on the structures and mechanisms of complex metalloproteins and integral membrane proteins, particularly those involved in ATP-dependent transduction processes. Distinct from most of the other structural biology groups working with purified macromolecules, the Chang lab utilizes cryo-electron tomography ( cryo-ET ), a powerful cryo-electron microscopy imaging . Our most recent efforts combine directed evolution, simulation, and machine learning to optimize .

Structural Mechanics; Interdisciplinary Studies Program. BMC Structural Biology is an open access peer-reviewed scientific journal that covers research in structural biology. Director of the Caltech MEMS Lab MEMS, Bio-MEMS, Micromachining, lab-on-a-chip, microfluidics, drug delivery, micro implants, circulating tumor cell, parylene, Bio-med Matt Thomson within the division of biology and biological engineering at caltech, computational biology questions that form the focus of current research efforts include how to model and understand the role of protein structures, how to interpret and analyze genomics data, and what are the best ways to perturb and control biological systems to reveal their Supervised by Taylor Stevens. Assistant: Cheryl Nakashima. Dual Affiliation with Division of Biology and Biological Engineering. 1200 East . 1200 E California Blvd. Shu-ou Shan Executive Officer Phone: (626) 395-3879 Office: 109 Braun E-mail: sshan@caltech.edu The research was done in the laboratory of Viviana Gradinaru (BS '05), assistant professor of biology . e-mail clemons@ Phone x1796 / Lab x1728 Address 1200 E California Blvd MC 114-96, Pasadena, CA 91125. The Chang lab in the University of Pennsylvania is deeply interested in understanding the basics of biology from a structural perspective. Karen Orta (Caltech) Structural insights behind phage single-gene lysis protein E 1:25 - 1:40 Maria Flores (UCLA) CryoEM structure of human CPEB3's reversible prion-like domain . The chemistry program at Caltech provides depth in the traditional areas of chemistryorganic and inorganic chemistry, chemical physics, theoretical chemistry, and chemical biology. Bren Professor of Biology and Chemistry. In the Gradinaru Lab, Xiaozhe is working on developing new molecular tools and viral vectors for neuroscience. Understanding life at molecular level. Caltech Structural Biology Group STRUCTURAL BIOLOGY at CALTECH Andre Hoelz Lab Bil Clemons Lab David Chan Lab Douglas C. Rees Lab Grant Jensen Lab Pamela J. Bjorkman Lab Stephen L. Mayo Lab Macromolecular Crystallography Lab Molecular Observatory for Structural Molecular Biology Structural Biology @ Caltech Loading. February 12, 2015. Active involvement in research, particularly during the . Our research in the Laboratory of Structural Biology aims at understanding the structure and function of biological macromolecules and their complexes, such as those involved in cellular cargo transport, protein folding, cell-cell contacts and viral infection. These three chemists and one physicist, all Nobel laureates, played a pivotal role in the creation of a new and pervasive branch of biology. Undergraduate Mechanical Engineering Division of Engineering and Applied Science Caltech Course Catalog. Access to over 40,000 titles, books, and videos across areas including programming, data analysis, math, science, engineering, business, arts, psychology, economics, political science, history, and more. Such structural meta-materials exhibit superior thermomechanical properties at extremely low mass densities (lighter than aerogels), making these solid foams ideal for many scientific and technological applications, especially in the medical field. Biological and Cryogenic Transmission Electron Microscopy at Caltech > Molecular Observatory for Structural Molecular Biology at Caltech > Stanford Synchrotron Radiation Facility > Advanced Light Source > Advanced Photon Source >. Now, a new technique developed at Caltech can render intact bones transparent, allowing researchers to observe these stem cells within their environment. Caltech Engineering and Applied Science Department of Aerospace (GALCIT) . In the Gradinaru Lab, Xiaozhe is working on developing new molecular tools and viral vectors for neuroscience. have the basic skills in mathematics, physics, chemistry, information science, computing, biology, engineering to address problems in their chosen discipline, be able to communicate this scientific and engineering knowledge to peers, experts, and the public, and . . Structural Biology of Immune Recognition of Pathogens Our laboratory is interested in immune recognition of viral pathogens. Powered by Create your own unique website with customizable templates. Tweets by clemonslab The option serves as a basis for graduate study in any field of biology or for admission to the study of medicine. Aaron Ames. Here at Caltech, we have access to leaders in several keystone areas of biology, including professors Rebecca Voorhees (co-author on the published manuscript), Bil Clemons, and Shu-ou Shan in structural biology, all of whom were willing to discuss ramifications of our data and provide expertise in this relatively new area for us." 451-453. Bio. As a research scientist and writer with Dr. Grant Jensen at Caltech, she helped the lab develop and apply cryo-electron tomography imaging to structural cell biology. pp. The physical cornerstone of the initiative was the Broad Center for the Biological Sciences, made possible by a lead gift of $18 million from The Eli and Edythe Broad Foundation. To expand her structural biology skill set, she undertook postdoctoral training at Caltech in the lab of Dr. Doug Rees where she characterized the structure and function of the Neisseria meningitides methionine ABC transport system using x-ray crystallography and single-particle cryo-EM. My laboratory pioneered methods to direct the evolution of enzymes, and we continue to refine and develop new approaches to protein engineering. the division of biology and biological engineering welcomes applications in all areas of biological science and biological engineering, with particular interest in exceptionally creative individuals who are interested in pursuing research in areas that benefit from the interdisciplinary environment of caltech's bbe division and its linkages to MC 155-44, Pasadena . The major focus of the group seeks a chemical-scale understanding of ion channels and neuroreceptors. Structural Mechanics; Interdisciplinary Studies Program. and structural loading or expansion of vehicle performance envelopes during travel. . Przemyslaw Dutka PhD student in the Jensen and Shapiro Labs @Caltech Structural Biology | Protein Engineering Greater Chicago Area 165 connections Astrid P Heikema1,2, Anthony P West Jr1 and Pamela J Bjorkman1,2 Address: 1Division of Biology 156-29 California Institute of Technology Pasadena, California 91125, USA, 2Howard Hughes Medical .

The Dougherty group in the Division of Chemistry and Chemical Engineering at the California Institute of Technology conducts research in organic chemistry and chemical biology. Protein structural biology in the era of high-accuracy structure prediction. B.S., Pennsylvania State University, 1983; Ph.D., Caltech, 1987. .

. Prof. Paul Freemont's research focuses on the molecular mechanisms of human disease using the tools of integrated structural biology comprising X-ray crystallography, Cryo-EM and associated biophysical, spectroscopic and cellular techniques.In addition, Prof. Freemont is an internationally-leading synthetic biologist with active research interests in cell-free biotechnologies and global health . Current year files are for the 2021-2022 academic year. Facilities. People Prof. Bil Clemons (CV March 2021) Arthur and Marian Hanisch Memorial Professor of Biochemistry Post Doc, Harvard Medical School (2001-2005) . RIKEN Structural Biology Laboratory, Kanagawa 230-0045, Japan. Microbial Cell Biology. California Institute of Technology. Powered by Create your own unique website with customizable templates. . Xiaozhe received his BS from Tsinghua University, Bejing, China in 2014. hhmi. Shinae Park, B.S. John R. Desjarlais, Stephen L. Mayo, Editorial overview: Computational protein design, Current Opinion in Structural Biology, Volume 12, Issue 4, 1 August 2002, Pages 429-430, ISSN 0959-440X, 10.1016/S0959-440X(02)00343-3. . Caltech laboratories are using structural biology, molecular biology, and mouse genetics to study how the immune system develops, how the immune system interacts with microbes that naturally reside in our bodies and are not pathogens, and how signals are transduced in both the innate and adaptive branches of the immune system. PDF Supp. The Interdisciplinary Studies Program (ISP) enables students to craft custom-tailored curriculacomprising Caltech courses, academic-year research, courses at other schools, or independent study courses in collaboration with faculty advisors. Bren Professor of Mechanical and Civil Engineering and Control and Dynamical Systems Professor Ames' research interests center on robotics, nonlinear control, hybrid systems and cyber-physical systems, with special emphasis on foundational theory and experimental realization on robotic systems; his lab designs, builds and tests novel bipedal robots and prosthesis with the goal of . Presenter: Benjamin Basanta Panelists: Mark Herzik, Jose Rodriguez and Elizabeth Villa . Major. To date we have imaged nearly 100 microbial species by cryoET. The metalloprotein work defined the unusual structures of the nitrogenase FeMo-cofactor and the more widespread Mo-cofactor that .

The unifying theme to her work is an experimental and theoretical approach at the intersection . electrophysiology, and computer modeling, detailed structural . Before joining Caltech, he was involved in multiple projects on structural biology and protein engineering. California Institute of Technology, Chemistry Major, First Year. Human neutralizing antibodies (hNAbs) that target the host ACE2 receptor-binding domain (RBD) of the SARS-CoV-2 spike show therapeutic promise and are being evaluated clincally. Pamela Bjrkman, Ph.D. Pamela Bjrkman, Ph.D., the David Baltimore Professor of Biology and Biological Engineering at the California Institute of Technology, will present the 34th annual Bertram M. Marx Lecture, hosted by the University of Alabama at Birmingham Department of Microbiology, Tuesday, March 1, from noon to 1 p.m. Bjrkman, a member of the prestigious National Academy of . . Caltech Biology & Biological Engineering Caltech Biology & Biological Engineering California Institute of Technology. In particular, we have placed a major emphasis on developing quantitative methods for protein design with the goal of developing a fully systematic design strategy that we call "protein design automation." Molecular Insights into Parkinson's Disease. The video collection currently includes over 800 self-paced tutorials of varying duration (from 2 to over 98 hours). A faculty member serves as the representative for an option. California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, USA. Facing a challenge akin to solving a 1,000-piece jigsaw puzzle while blindfoldedand without touching the piecesmany structural biochemists thought it would be impossible to determine the atomic structure of a massive cellular machine called the . Plckthun, Andreas and Mayo, Stephen L. (2007) The design of evolution and the evolution of design. Bil Clemons, PhD Professor of Biochemistry. We can't do everything.yet, so we currently work on problems related to protein transport across membranes and post-translational modification of proteins. Biochemistry & Molecular Biophysics | Division of Chemistry and Chemical Engineering Biochemistry & Molecular Biophysics Biochemistry and Molecular Biophysics has been established as an interdisciplinary program, at the interface of biology, chemistry, and physics, that seeks to understand the basic molecular mechanisms of life. BMC Structural Biology BMC Structural Biology 2002, 2Research article x Open Access (ILT2) in regions implicated in the binding of the Human . Steve Mayo is the Bren Professor of Biology and Chemistry at the California Institute of Technology in Pasadena, California. The focus of the lab is the coupling of theoretical, computational, and experimental techniques for the study of structural biology. We are particularly interested in understanding the immune response against HIV-1 and influenza in order to develop improved therapeutics. Structural Biology @ Caltech Loading. Caltech Biochemist Sheds Light on Structure of Key Cellular 'Gatekeeper'. Architects of Structural Biology is an amalgam of memoirs, biography, and intellectual history of the personalities and single-minded devotion of four scientists who are among the greatest in modern times. and provides general supervision to undergraduate and/or graduate students in the option. Before joining Caltech, he was involved in multiple projects on structural biology and protein engineering.

Journal of Theoretical Biology, 2012. Marshall, John M., and Hay, Bruce A. biology, engineering, medicine, and biophysicscreating a rich . ImYoo launched with Caltech alumni CEO Tatyana Dobreva (PhD 2021) and CTO David Brown (PhD 2021) along with seed funding from the Fund@Caltech and the Illumina Accelerator. molecular and cellular biology laboratories are investigating the underlying molecular mechanisms of fundamental cellular and organismal processes including the replication, expression, and repair of the genome, transduction of signals from the cell surface to the nucleus in response to diffusible signals or cell-cell interaction, protein A list of current faculty option representatives and their . Ph.D. Molecular Biology, University of California, Los Angeles (2021) Xiaozhe received his BS from Tsinghua University, Bejing, China in 2014. Since 1963, the Fannie and John Hertz Foundation has awarded over 1,100 doctoral fellowships with the goal of supporting the early stage research endeavors of applied physical, biological, and engineering science students who possess the potential to change our world for the better by solving difficult, real-world problems. The Interdisciplinary Studies Program (ISP) enables students to craft custom-tailored curriculacomprising Caltech courses, academic-year research, courses at other schools, or independent study courses in collaboration with faculty advisors. The aim of this undergraduate program is to provide thorough training in the geological and planetary sciences and, wherever possible, to integrate these studies with courses in mathematics, physics, chemistry, and biology taken during the student's earlier years at the Institute. Research. The COVID-19 pandemic presents an urgent health crisis. ISSN . At Guttman Lab, we aim to understand how noncoding RNAs shape dynamic nuclear structure to regulate gene expression. The option representative provides consultation on academic programs, degree requirements, financial aid, etc. California Institute of Technology. Before joining Caltech, he was involved in multiple projects on structural biology and protein engineering. Structural Biology and Biochemistry, The Rockefeller University (2003) M.Sc. 1200 East California Boulevard . This minor is intended to supplement one of Caltech's undergraduate degrees and is designed for students who wish to broaden their knowledge beyond their normal major, especially for those who wish to join the structural engineering profession after graduation or pursue a graduate degree in structural mechanics or structural engineering. e-mail clemons@ Phone x1796 / Lab x1728 Address 1200 E California Blvd MC 114-96, Pasadena, CA 91125. 2 Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, 6703 HB Wageningen, Netherlands. . Much of our research focuses on dissecting microbial cell biology, with a particular emphasis on cellular nanomachines. Bio. Wikimedia Commons has media related to Media from BMC Structural Biology In addition to imaging small cells, we have also made a major investment into the structural biology of the human immunodeficiency virus type 1 (HIV). Minor. In 2021, she joined the Gradinaru lab and is excited to serve as project manager for the Aligning Science Across Parkinson's team. with particular emphasis on topics relevant to biology, energy, and the environment. . Contact. In: Molecular Biology of Neurodegenerative Diseases. 2 Howard Hughes Medical Institute, Pasadena, California 91125. In the Gradinaru Lab, Xiaozhe is working on developing new molecular tools and viral vectors for neuroscience. . Contact. The archive on this site houses the previous ten years' Catalog files, with a link to the repository of all Catalog files maintained by the Caltech Library. We develop cutting-edge technologies based in biochemistry, cell biology, genomics and computational biology to address these questions. Graduate Program computational mechanics and structural dynamics to study natural ground surface features and man-made geotechnical systems --such as ridges, valleys, dams, tunnels, building foundations and offshore structures.

We strive to decipher basic . A Practical Guide to Single-Particle Cryo-EM: From Biochemistry to Atomic Models - a recent review by Michael A. Cianfrocco and Elizabeth H. Kellogg; Prof. Jensen's online videos on the theory and principles of cryo-EM (14 hours) This research sparked Dr. Sharaf's current interest in . RESEARCH TECHNICIAN Cellular Electron Cryotomography: Toward Structural Biology In Situ - CaltechAUTHORS Electron cryotomography (ECT) provides three-dimensional views of macromolecular complexes inside cells in a native frozen-hydrated state. The method is a breakthrough for testing new drugs to combat diseases like osteoporosis. (Diplom) Chemistry and Biochemistry, University of Freiburg, Germany (1997) .